‘पाथजेनी’ (PathGennie): भारतीय वैज्ञानिकों का वह ‘जादुई चिराग’ जो बदल देगा नई दवाओं की खोज का तरीका

‘पाथजेनी’ (PathGennie): भारतीय वैज्ञानिकों का वह ‘जादुई चिराग’ जो बदल देगा नई दवाओं की खोज का तरीका: IN THE DEVELOPMENT OF NEW PHARMACEUTICALS, UNDERSTANDING THE “RESIDENCE TIME”—HOW LONG A DRUG MOLECULE STAYS ATTACHED TO ITS TARGET PROTEIN—IS OFTEN MORE CRITICAL THAN BINDING AFFINITY ALONE. HOWEVER, SIMULATING THE UNBINDING PROCESS (THE DRUG LEAVING THE PROTEIN POCKET) IS COMPUTATIONALLY EXPENSIVE. THESE “RARE EVENTS” HAPPEN ON TIME SCALES OF MILLISECONDS TO SECONDS, WHICH IS CHALLENGING